Fig. 4

Effect size for bioluminescence and number of nodules in the cecum of the orthotopic mouse model after a 6-week treatment. a After a 6-week treatment, an effect size of 79% increase in bioluminescence for EntF* compared to the placebo was observed, while for the positive control EGF, a median effect size of 316% was obtained. When calculating the effect size according to Hedges’ G values, a medium to large effect was observed for both EntF* and EGF treatment groups, compared to the placebo group. b After a 6-week treatment, a 3-fold increase in the number of nodules on the cecum was observed for EntF* compared to the placebo PBS, while for the positive control EGF, a 4.5-fold increase was obtained. When calculating the effect size according to Hedges’ G values, a medium and large effect was observed for the EntF* and EGF treatment groups, respectively, compared to the placebo group [Fig. prepared in R-script: https://github.com/JoachimGoedhart/PlotsOfDifferences]