Fig. 4
From: The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential
H3K27M mutation alters gene expression during neural cell specification. A Principal component analysis plot for RNA-seq datasets, corresponding to 8 H3K27M and 4 WT biological replicate samples for each time point (day 0, day 5). B Numbers of differentially expressed genes (DEGs) in comparisons between WT and H3K27M mutant clones 1 and 2, at day 0 and day 5. C Venn diagram shows the shared and H3K27M mutant clone specific DEGs at day 0 and day 5. D Unsupervised hierarchical clustering defined 5 clusters of genes (clusters a–e) that exhibit differential expression in WT versus H3K27M clones