Fig. 7
From: The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential
Enriched pathways and gene networks with increased expression in H3K27M cells relative to WT, H3K27me3 peaks, and DNA methylation loss at day 5. A Analysis of H3K27me3 peaks at genes with increased expression in mut vs WT at day 5 reveals an enriched network of genes involved in central nervous system development. B List of genes with H3K27me3 peaks, increased expression in H3K27M cells relative to WT and DNA methylation loss at day 5. C Gene ontology analysis of the genes in B reveals enrichment in pathways involved in brain neoplasms, synapses, and Notch signaling. D A graphical representation of an enriched network of genes related to Notch signaling