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Fig. 7 | BMC Biology

Fig. 7

From: Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster

Fig. 7

Transport mechanism and physiological function of CG4562/dMRP5. CG4562/dMRP5, which is a typical ABC transporter, facilitates heme transport out of cells with ATP hydrolysis. Heme, as an alternative iron source, is absorbed from outside of cells or synthesized in the mitochondria of the flies. Excess heme in the gut cells is degraded by heme oxygenase or detoxifies/effluxes by CG4562/dMRP5 located on the basolateral side of the enterocyte

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