Fig. 7From: Identification and characterization of a heme exporter from the MRP family in Drosophila melanogasterTransport mechanism and physiological function of CG4562/dMRP5. CG4562/dMRP5, which is a typical ABC transporter, facilitates heme transport out of cells with ATP hydrolysis. Heme, as an alternative iron source, is absorbed from outside of cells or synthesized in the mitochondria of the flies. Excess heme in the gut cells is degraded by heme oxygenase or detoxifies/effluxes by CG4562/dMRP5 located on the basolateral side of the enterocyteBack to article page