Fig. 5
From: Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis
Hybrid modelling of Pks13. a With the most probable population superposed on the envelope. The Pks13 insertion is circled in dark grey. b With the three populations constituting the minimal ensemble, independently fitted within the envelope. c With the three populations aligned via ACP1-KS-AT. Equivalent residues known to interact with the C16 substrate analogue in the complex between AcpP and the ketosynthase FabF (E. coli) and residues interacting with CoA of the α-chain in the AT of Pks13 are highlighted in red on the corresponding KS and AT domains. Colour code: ACPs, red; KS, green; AT, yellow; TE, dark blue; linker regions, light grey; Pks13 insertion, dark grey