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Table 1 Effect of CA-IX expression on metastasis of MCF-7 cells. (Two-tailed Fisher’s exact t-test)

From: Proton export upregulates aerobic glycolysis

Mouse Model

Experimental metastasis

 

Spontaneous metastasis

 

# of mice with lung mets

p-value (**p<0.01)

# of mice with lung mets

p-value

MCF7/parental

0/5 (0%)

   

MCF7/MOCK-2

0/6 (0%)

 

1/10 (10%)

 

MCF7/ CA-IX M1

4/7 (57%)

0.07 (n.s.)

0/15 (0%)

 

MCF7/ CA-IX M6

6/6 (100%)

0.0022**

6/21 (29%)

0.37 (n.s.)

  1. **p<0.01