Fig. 4
From: Hematopoietic differentiation persists in human iPSCs defective in de novo DNA methylation
Comparison of DNA methylation profiles of all iPSCs, iMSCs and iHPCs. a Principal component analysis of global DNA methylation profiles of all iPSC lines and derived iMSCs or iHPCs (D = donor, WT = wildtype, Ex = exon). b Epi-Pluri-Score analysis of all generated cell lines and their progeny. c Venn diagram showing overlap of CpGs that were >50% hypermethylated during differentiation of iPSCs into iMSCs or iHPCs (mean of two biological replica, each). d Heatmap showing the top 10 transcription factor motifs enriched in these hypermethylated CpGs (compared to corresponding iPSCs)