Fig. 4
From: A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity
Binding affinity of gossypol derivative ST087010 to ZIKV proteins. Binding of ST087010 or gossypol control to ZIKV full-length envelope (E) protein (A), domain III of E (EDIII) protein (B), or NS2B-NS3 (C) protein was assessed by ELISA. The data are expressed as the mean ± s.e.m. of 4 wells, and DMSO was used as the negative control. Surface plasmon resonance (SPR) analysis of the binding between ST087010 and ZIKV EDIII (D) or NS2B-NS3 (E) protein. Binding affinity was shown as KD (equilibrium dissociation constant). The experiments were repeated twice with similar results