Fig. 7

Safety profile of gossypol derivative ST087010 in pregnant Ifnar1^−/− mice and their pups. A Weight changes of pregnant mothers at prenatal and postnatal time points. B Weight changes of pups at different postnatal time points. Alanine transaminase (ALT) (C) and creatinine (D) levels in sera of pregnant mice were measured by ALT assay and creatinine assay, respectively, before and 4 h, 1, 3, and 5 days post-last injection of ST087010 or DMSO control. The data (in A–D) are expressed as the mean ± s.e.m. of 5 mice in each group, and significant differences (*) between ST087010 (40 mg/kg) and DMSO groups at 1 day post-treatment are shown (in C, D). E Hematoxylin and eosin (H&E) staining of tissues, including the liver, spleen, kidney, and brain, from ST087010 or DMSO-treated mothers and their pups. Scale bar, 50 μm