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Table 1 Cytotoxicity and in vitro inhibitory activity of gossypol derivative ST087010 against infections of DENV-1-4 strainsa

From: A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity

Gossypol derivative

CC50 (μM)

IC50 (μM)

DENV-1-V1792

SI

DENV-2-V594

SI

DENV-3-V1043

SI

DENV-4-PR-06-65-740

SI

ST087010

47.20 ± 1.35

3.01 ± 0.11

15.7

3.19 ± 0.01

14.8

3.33 ± 0.08

14.2

2.98 ± 0.18

15.8

Gossypol

19.06 ± 1.09

2.06 ± 0.13

9.3

1.91 ± 0.01

10.0

3.42 ± 0.11

5.6

2.83 ± 0.07

6.7

  1. aThe cytotoxicity and inhibitory activity of gossypol derivative ST087010 were assessed in LLC-MK2 cells, and gossypol was included as a control. Cytotoxicity is expressed as CC50. Inhibitory activity against DENV-1-4 infections is expressed as IC50. Selectivity index (SI) was calculated based on the values of CC50/IC50. The data are presented as the mean ± standard error of the mean (s.e.m.) of duplicate wells. The experiments were repeated twice with similar results
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BMC Biology

ISSN: 1741-7007

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