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Table 1 Cytotoxicity and in vitro inhibitory activity of gossypol derivative ST087010 against infections of DENV-1-4 strainsa

From: A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity

Gossypol derivative CC50 (μM) IC50 (μM)
DENV-1-V1792 SI DENV-2-V594 SI DENV-3-V1043 SI DENV-4-PR-06-65-740 SI
ST087010 47.20 ± 1.35 3.01 ± 0.11 15.7 3.19 ± 0.01 14.8 3.33 ± 0.08 14.2 2.98 ± 0.18 15.8
Gossypol 19.06 ± 1.09 2.06 ± 0.13 9.3 1.91 ± 0.01 10.0 3.42 ± 0.11 5.6 2.83 ± 0.07 6.7
  1. aThe cytotoxicity and inhibitory activity of gossypol derivative ST087010 were assessed in LLC-MK2 cells, and gossypol was included as a control. Cytotoxicity is expressed as CC50. Inhibitory activity against DENV-1-4 infections is expressed as IC50. Selectivity index (SI) was calculated based on the values of CC50/IC50. The data are presented as the mean ± standard error of the mean (s.e.m.) of duplicate wells. The experiments were repeated twice with similar results