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Table 2. All the heatmap clusters which include outlier genes are listed with their expression description, their classification (if one had been assigned) and the outlier genes separated by whether they were from hearing difficulty outlier lists or normal hearing outlier lists. Thirteen genes are present in both a hearing difficulty outlier list and a normal hearing outlier list. Known deafness genes are in bold. RM: Reissner's membrane; OC: Organ of Corti; LW: lateral wall; SGN: spiral ganglion neurons; SC: supporting cell; HC: hair cells; OHC: outer hair cells; IHC: inner hair cells; IPhC: inner phalangeal cells; DC: Deiters' cells; PC: pillar cells

From: Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank

  Genes in hearing difficulty outlier lists Genes in normal hearing outlier lists
Cluster 1A
Middle in RM and OC, mid-low in LW, low in SGN and SC
Cells of the cochlear duct (Myh14)
Mrpl38, Trp53i13, Dnpep, Atp6v0a2, Arhgap17, Myh14, Tgfbr1, Itgb1bp1 Krt10, Yy1, Prkra, Txndc16, Nsrp1, Sap30bp, Gpr180, Maz, Rae1, Zfpl1, Itgb1bp1, Dpp7, Proser2
Cluster 1B
High in HC, mid-high in rest of OC, middle in RM, mid-low in LW, low in SC
Organ of Corti and fibrocytes
Ddx52, Dxo, Acp6, Rrp9, Itsn2, Dlg5, Ptpn13 Lmf2, Gas8, Svil, Mus81
Cluster 1C
High in OHC, middle in rest of OC and RM, mid-low in LW, low in SC and SGN
Outer hair cells
Snapc3, Mink1 Mink1, Prdm2, 4932438A13Rik
Cluster 1D
High in OHC, mid-high in rest of OC, mid-low in LW and SC, low in RM and SGN
Hair cells (Synj2)
Ube3b, Synj2, Tacc2 Mpdz, Tacc2, Hyou1
Cluster 1E
Mid-high in HC, middle in rest of OC, middle in fibrocytes, mid-low in RM and SC, low in rest of LW and SGN
Hair cells
Madd Ubr4, Peg3, Cadm1
Cluster 1F
Mid-high in OHC, middle in rest of OC, middle in RM, fibrocytes, Hensen cells and IPhC, mid-low in rest of SC and rest of LW, low in SGN
Outer hair cells
Brd4, Ubtf, Bri3bp, Sfxn5, Nav2 Srp68, Kdm5a, Nav2
Cluster 1G
Mid-high in OC and RM, mid-low in LW, SC, low in SGN
Organ of Corti and Reissner’s membrane
Kmt2c, Agrn, Htt Gramd1a, Kdm1a, Agrn, Leng8
Cluster 1H
Mid-high in HC and RM, mid-low in rest of OC, LW, SC, low in SGN
Hair cells and Reissner’s membrane
Vwa8, Vps13b, Cgn Atr, Sgip1
Cluster 1I
Low in SC, SGN and marginal cells, middle in OC, RM and rest of LW
Numa1, Pdlim5, Hnrnpa0, Pam Dmxl1, Arid1b, Polg, Numa1, Tjp1, Etl4
Cluster 1J
Middle in OHC, RM and rest of LW, low in rest of OC, spindle/root cells, SC and SGN
  Rin2
Cluster 1K
Mid-high in pillar cells, middle in rest of OC, fibrocytes and IPhC, low in rest of LW, rest of SC, SGN and RM
Pillar cells
Adamts2, Me3, Col11a1, Lamb2, Itpr2, Fzd9 Zfpm1
Cluster 1L
Middle in pillar cells and fibrocytes, mid-low in RM, OHC, basal cells, spindle and root cells, low in rest of OC, rest of LW, SC and SGN
Lama2 Hmcn1, Rgs3, Pgm5, Synm, Rcl1, Lama2
Cluster 1M
Mid-high in LW, middle in OC, mid-low in SC, low in SGN and RM
Stria vascularis (Kcnj10)
  Slc12a2
Cluster 1N
Mid-high in OC, low in LW, SGN, SC and RM
Hair cells (Pcdh15)
Grwd1, Surf6, Tjap1, Tmprss9 Eif2b3, Grwd1, Nop9, Celsr1, Man2b2, Tcerg1, Cog4, Sema6d, Rgs11
Cluster 1O
High in HC, middle in PC, low in DC, SGN, RM, LW and SC
Hair cells (Atoh1, Pou4f3, Otof)
Fscn2, Chrna10, Lmod3 Lmod3
Cluster 1P
High in HC, low in rest of OC, SGN, RM, LW and SC
Hair cells (Myo7a, Ptprq)
Cdh23, Loxhd1 Osbp2
Cluster 1Q
High in HC, middle in DC, low in PC, SGN, RM, LW and SC
Hair cells (Tmc1)
Tmc1, Strip2 Tmprss7
Cluster 1R
High in OHC, mid-high in rest of OC, mid-low in SC, low in LW, RM and SGN
Organ of Corti
  Rnf128, Otog, Dnaja4, Ush1c
Cluster 2A
Middle in OC and RM, mid-low in LW, low in SC and SGN
Atxn7, Noc2l, Nob1, Capn10, Cog1, Iqcb1, Elmo3, Slc9a8, Aldh4a1, Szt2, Dach1, Tcirg1, Pkp3, Chmp4c Rfx7, Fggy, Cep295, Zfp142, Sec24d, Pld2, Lgr4, Dock6, Baz1a, Gli3, Sft2d3, Abca3, Slc39a3, Cnksr1
Cluster 2B
Middle in OC, mid-low in LW, low in RM, SC and SGN
Vps13a, Rbl2, Manea, Cep63 Diaph1, Vps13a, Ints1, Abcb8, Flna, Maml2, Nectin1, Klhdc10, Plec, Fam189b
Cluster 2C
Low in DC, middle in rest of OC, low in LW, SC, RM and SGN
Frmpd1, Hgh1, Myom1 Hectd4, Frmpd1, Tsr1
Cluster 2D
Middle in SGN and RM, mid-low in OC, low in SC and LW
Spiral ganglion neurons
Tango2, Prune2 Ercc6, Kif1a
Cluster 2E
Middle in HC, low in rest of OC, LW, SC, RM and SGN
Hair cells (Whrn)
Dll3, Ppp6r2, Fer1l6, Rimkla Dll3, Pkhd1l1, Fam81b, Pdzd7, Adgrv1, Xirp2, Myo3a, Angpt1, Abca7, Obscn, Mn1, Dvl3, Pjvk, Ltbp1
Cluster 2F
High in OHC, middle in IHC, low in rest of OC, LW, SC, RM and SGN
Outer hair cells (Slc26a5)
Gpr152, Slc26a5  
Cluster 2G
High in OHC, low in rest of OC, LW, SC, RM and SGN
Outer hair cells
Bmp3 Tub, Sec16b
Cluster 2H
Middle in fibrocytes, mid-low in rest of LW and SC, low in RM, SGN and OC
Fibrocytes
Mylk Lamb1, Afap1l2, Fbln7, Wfdc1
Cluster 2I
Mid-high in IHC, middle in DC and PC, low in OHC, LW, SGN, SC and RM
Inner hair cells
  Dmd, Piezo1
Cluster 2K
Mid-high in PC, middle in RM, fibrocytes and spindle/root cells, low in rest of OC, rest of LW, SGN and SC
Pillar cells
Thsd7a  
Cluster 2L
Middle in RM and fibrocytes, mid-low in rest of LW, low in OC, SC and SGN
  Pcolce, Ccdc141
Cluster 2M
High in RM, mid-high in spindle/root cells, low in rest of LW, SGN, SC and OC
Reissner’s membrane
Ap1s3, Atp13a5, Slc26a7 Frem1, Slc26a4
Cluster 3A
Middle in OC, RM, LW and SC, low in SGN
Cochlear epithelium (Sox10)
Eif5b, Tcn2, Sdf2l1, Auts2, Mpnd, Sipa1l1 Abhd14b, Zfhx3, Syne2, Nadk
Cluster 3B
High in OHC, mid-high in IHC, middle in rest of OC, RM, LW and SC, low in SGN
Hair cells (Myo6)
Nbeal1, Myo6 Brd2, Hspa4
Cluster 3C
High in PC, low in marginal cells, RM and SGN, middle in rest of OC, rest of LW and SC
Pillar cells
Txndc5, Irf2bpl Ddrgk1
Cluster 3D
Low in marginal cells and SGN, middle in OC, RM, rest of LW and SC
Dguok, Fndc3a, Asap1 Kdm6b
Cluster 3E
Low in SGN, marginal and intermediate cells, high in PC, mid-high in rest of OC, fibrocytes and IPhC, middle in RM, rest of SC and rest of LW
Sensory epithelia (Six1)
Igfbp5 P3h4, Col11a2
Cluster 3F
High in OC, middle in RM, SC and spindle/root cells, low in rest of LW and SGN
Organ of Corti
Dpp4  
Cluster 3G
High in OC, IPhC and spindle/root cells, middle in RM, rest of SC and fibrocytes, low in SGN and rest of LW
Organ of Corti, inner phalangeal and spindle/root cells
  Gpx2
Cluster 3H
High in HC, mid-high in rest of OC, middle in SC, mid-low in LW and SGN, low in RM
Hair cells
Ciapin1, Kif21a Nceh1, Ciapin1
Cluster 3I
Middle in DC, high in rest of OC, fibrocytes and spindle/root cells, middle in rest of LW and SC, mid-low in SGN, low in RM
Cells of the cochlear duct
Prdx5, Ndufv3 Srp14, Capns1
Cluster 4A
Middle in marginal cells, high in rest of LW, OC, RM and SC, low in SGN
Cells of the cochlear duct
Gjb2