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Table 2 Cell division defects found in CRS-depleted HeLa cells

From: Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus

  

Mock

Scramble

BAF53a

CFDP1

GAS41

MRG15

p400

Tip60

YL1

Metaphase

MS

1.43 ± 1.47

0 ± 0

3.12 ± 3.35

0.43 ± 0.74

12.77 ± 3.13***

3.23 ± 2.01

11.95 ± 0.74***

10.77 ± 3.27***

10.49 ± 2.80***

CM

2.03 ± 1.76

0.79 ± 1.37

29.00 ± 2.06***

23.90 ± 6.11***

31.60 ± 3.00***

7.16 ± 1.85*(Scramble)

2.74 ± 0.85

29.80 ± 3.10***

34.98 ± 4.72***

Telophase

CB

0.87 ± 1.52

0.56 ± 0.98

15.86 ± 0.57***

30.16 ± 1.96***

1.80 ± 0.97

4.13 ± 0.95***

1.29 ± 0.14

4.55 ± 3.75***

1.83 ± 0.39

LIB

0.44 ± 0.20

0.62 ± 0.30

30.27 ± 2.79***

0.57 ± 0.51

9.41 ± 1.54***

3.19 ± 1.74***

0.84 ± 0.36

4.88 ± 2.75***

8.32 ± 3.29***

MC

1.40 ± 1.03

1.55 ± 1.21

5.96 ± 0.90***

4.02 ± 1.99***

2.89 ± 0.90***

6.87 ± 1.36***

4.98 ± 0.89***

3.09 ± 1.27***

2.47 ± 0.65***

  1. MS multipolar spindles, CM chromosome misalignments, CB chromatin bridges, LIB long intercellular bridges, MC multinucleated cells
  2. The results are expressed as mean ± SD values from three independent replicate experiments. Experimental groups were compared with control groups (mocks and scrambles) by Fisher’s exact test. *=P < 0.05; **P= < 0.005; and ***=P < 0.0005
  3. *(Scramble)=This means that it is statistically significant only with the scramble