Fig. 1

lncRNA TUG1 expression is increased in human skeletal muscle in response to a single bout of aerobic exercise. Gene expression of A TUG1, B PPARGC1A and C TFAM measured by RT-qPCR from muscle (vastus lateralis) biopsy samples before (Pre Ex), immediately (Post 0 h) and 3 h after (Post 3 h) a 60-min bout of cycling exercise at 70% VO_2peak. Matching point colours represent the same male (triangles, open bars) and female (circles, shaded bars) participants across all time points; bars are mean (SD) for n=7 subjects/sex. Data were analysed by repeated measures two-way ANOVA for main effects of sex and time. Significant interactions were analysed with Tukey post hoc test: *p < 0.05, **p < 0.01, ***p < 0.001 male vs. female. D Correlation between TUG1 and PPARGC1A in males and females at Post 3 h; dotted lines represent 95% CI. See also Additional file 1: Supplementary Fig. S1