Skip to main content

Table 1 Growth inhibition assay in the P. falciparum cultures done in ghost RBC preparations treated with 10 µM fluorescein-labeled aggregative peptides conjugated to CPPs from Fig. 1D

From: The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures

Peptide sequence

Parasite growth relative to untreated control (%) ± SEM

p-value1

TAT

100.0 ± 0.9

 > 0.9999

TAT-LQSNIG

100.0 ± 17.5

 > 0.9999

TAT-NVNIYN

99.7 ± 5.2

0.9580

TAT-NFNNIYH

100.0 ± 10.8

 > 0.9999

TAT-NNFYYNN

100.0 ± 6.1

 > 0.9999

TAT-LISFIL

95.5 ± 6.4

0.5572

TAT-LYWIYY

100.0 ± 5.9

 > 0.9999

TP2

100.0 ± 9.5

 > 0.9999

TP2-LQSNIG

100.0 ± 4.2

 > 0.9999

TP2-NVNIYN

100.0 ± 12.0

 > 0.9999

TP2-NFNNIYH

100.0 ± 7.3

 > 0.9999

TP2-NNFYYNN

96.2 ± 0.3

0.7000

TP2-LISFIL

98.5 ± 0.5

0.0835

TP2-LYWIYY

84.9 ± 3.0

0.0374*

LMWP

90.9 ± 1.1

0.3430

LMWP-LQSNIG

75.2 ± 3.4

0.0188*

LMWP-NVNIYN

81.9 ± 10.1

0.2152

LMWP-NFNNIYH

66.2 ± 6.5

0.0349*

LMWP-NNFYYNN

73.6 ± 12.4

0.1665

LMWP-LISFIL

79.4 ± 9.3

0.1561

LMWP-LYWIYY

86.3 ± 6.4

0.1653

  1. 1p-value obtained applying two-sided Student’s t test in GraphPad Prism. *p ≤ 0.05