Fig. 7
From: Hmga2 protein loss alters nuclear envelope and 3D chromatin structure
Hmga2 KO alters inter-TAD interactions and their association with nuclear lamina. A The computational approach to analyze the effects of Hmga2 KO on inter-TAD interactions was to calculate the Log fold change between the interactions between TADs in wt and Hmga2 KO. B Fold changes between all TAD pairs were calculated for each chromosome; the graph reports the distribution of inter-TAD interactions in chromosome 1, showing that there are numerous interactions that are decreased or increased in Hmga2 KO cells compared to wt cells. C Genome-wide enrichment of DamID signal [33] in TAD pairs exhibiting the most prominent interaction change