Fig. 1

CamKIIa-Cre-mediated XRCC1 KO in different regions of the forebrain. A Breeding scheme used to obtain control and XRCC1 KO female and male animals. B Representative images showing staining of brain sections of control (left) and XRCC1 KO (right) male animals with XRCC1 antibodies (top) and Dapi (bottom) with a focus on the hippocampus. C Quantification of XRCC1 staining intensity as shown in B per area of interest in n = 3 per group. **p < 0.01 and ***p < 0.001 based on independent Student’s two-tailed t-test. Shown are all individual values, means ± SEM. D Representative images showing staining of brain sections of different hippocampal areas in control (top) and XRCC1 KO (bottom) male animals with γH2AX antibodies (red) and Dapi (blue). E Quantification of γH2AX staining intensity as shown in D per area of interest in n = 3 per group. *p < 0.05, **p < 0.01 and ***p < 0.001 based on independent Student’s two-tailed t-test. Shown are all individual values, means ± SEM