Fig. 2

CaMKIIa-Cre-driven XRCC1 KO does not cause changes in motor coordination, cognition or social behaviour. A Body weight (BW) of animals measured after testing at 17 weeks of age. B Accelerating rotarod test, showing time the animals stayed on the rotarod in s. C Spontaneous alternation test. The bar plots depict the percentage of alternation in the Y-maze for male (left) and female (right) XRCC1-KO and control mice. The dashed line indicates chance level (50%). D Y-maze spatial recognition test. The bar plots show the percent (%) time spent in the novel arm during the choice phase of the spatial working memory test in the Y-maze for male (left) and female (right) XRCC1-KO and control mice. The dashed line indicates chance level (33%). E Social interaction test. The bar plots depict the percent (%) time spent with an unfamiliar mouse (compared to an inanimate dummy) for both sex and groups. The dashed line indicates chance level (50%). A N = 6 Con and 4 KO males, 5 Con and 4 KO females; B, C, E N = 5 Con and 6 KO males, 5 Con and 5 KO females; D N = 10 Con and 7 KO males, 9 Con and 5 KO females. Shown are all individual values, means ± SEM