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Fig. 4 | BMC Biology

Fig. 4

From: Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells

Fig. 4

Significantly differentially expressed genes of cells in each cluster. The expression of 485 transcripts was determined by targeted amplification (BD Rhapsody system). Significant genes defined as adjusted p < 0.05 and log2 fold change > 0. Dot plot: fraction of cells in cluster expressing each gene shown by size of circle and level of expression shown from white (=0) to dark blue (=max, log2 scale). Red bars indicate genes that were significantly higher in one cluster compared to all other clusters of the parent cell type. There were no DEGs in NK or B cell clusters. A CD4+ T cells, B CD8+ T cells, and C monocytes. CM, classical monocytes; INT, intermediate monocytes; NCM, nonclassical monocytes. To denote each of the clusters, the letter “C” is used in CD4+ T and CD8+ T followed by the cluster number. In the case of monocytes, clusters are represented as INT, CM, or NCM followed by the cluster number

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