Fig. 4.

KIR allele associations with HLA alleles. a Bar plot depicting and listing KIR alleles that are significantly associated with HLA alleles at the FDR < 1e−10 level. b Volcano plot of KIR allele correlations with HLA alleles in UK Biobank. Associations are color-coded by the activity (inhibitory or activating) of the KIR allele. c Presence of at least 1 copy of HLA-A74 positively correlates with presence of at least 1 copy of KIR3DL3*005 (left) and presence of at least 1 copy of HLA-A36 negatively correlates with presence of at least 1 copy of KIR2DL3*002. d KIR t-SNE of UK Biobank individuals with those possessing HLA-B*42 highlighted in red. e Volcano plot of KIR allele correlations with HLA alleles among Caucasians in UK Biobank