Fig. 2

WGCNA model fit and soft threshold determination. Soft thresholding power analysis was used to obtain the scale-free fit index (ranging from 1 to 20) of network topology, for method #3 (A) and #2 and #4 (D), which until that step of the working pipeline are the same. Mean connectivity when using method #3 (B) and method #4 (E). The plot of log10(p(k)) vs log10(k) indicates that by using the chosen β value, C method #3 (β = 9) and F method #4 (β = 5), the network is close to a scale-free network because it is approximately following a straight line. k is the whole network connectivity and p(k) is the corresponding frequency distribution