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Fig. 9 | BMC Biology

Fig. 9

From: ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers

Fig. 9

Proposed model of H3.3 chromatin regulation by ARID1A-SWI/SNF and co-regulators. ARID1A and SWI/SNF chromatin remodeling activities are required for H3.3 incorporation or maintenance at certain active regulatory elements across the genome, such as super-enhancers. When ARID1A is mutated or lost, H3.3 maintenance is disrupted, and nucleosome composition shifts toward canonical H3.1/3.2 at ARID1A-bound sites. Consequential to local H3.3 depletion, H3.3 reader factor occupancy is reduced—such as the CHD4-containing NuRD complex—leading to impaired chromatin regulation and aberrant target gene expression. At H3.3+ H4K16ac+ super-enhancer-like elements located promoter-proximally upstream of genes, H3.3 maintenance by ARID1A-SWI/SNF is associated with repression of transcriptional hyperactivation and the NuRD cofactor ZMYND8

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