Fig. 3

The GD3 AF1_FFF uterus displays delay in cessation of epithelial cell proliferation. A Four samples from each genotype were stained with Ki67 antibody. Two of the WT samples are negative for Ki67 in the luminal epithelia (in red circles); in contrast, all 4 AF1_FFF samples are intensely Ki67-positive. The glandular staining of Ki67 in all 4 WT samples is largely absent but is strongly positive in the mutant (in green circles). The stromal cell proliferation in the WT uterus has notably initiated, but it was scarce in the mutant (in yellow circles). B The average percentage of Ki67-positive endometrial glands in AF1_FFF uteri is significantly higher than that in the WT uteri (p < 0.05, n = 4)