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Fig. 6 | BMC Biology

Fig. 6

From: Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Fig. 6

AF1 mediates the antagonistic and synergistic effects of progesterone on oestrogen action in OVX mice. A Progesterone failed to inhibit EB-induced uterine wet weight gain in AF1_FFF mice (n = 4 in control, n = 3 in EB- and EBP-treated samples. All data points are plotted, *p < 0.05). B, C Venn diagrams show gene regulation by EB and EBP in the WT and AF1_FFF uterus, respectively (padj < 0.05). The number in red ovals indicates genes commonly regulated between Ctrl and EB and between EB and EBP. The number in green ovals indicates genes significantly regulated by EBP compared to Ctrl but not by EB. The number in blue ovals indicates genes differentially regulated between EB and EBP, but not between Ctrl and EB, or between Ctrl and EBP. D The heatmap of the 386 genes in the red oval of B. Genes indicated by open brackets are oppositely upregulated by EB and progesterone; genes outside the brackets appear synergistically up- or downregulated by EB and progesterone. E The heatmap based on the transcripts of the 31 genes in the blue oval of B. Genes in the dotted rectangle appear oppositely regulated by EB and progesterone. F The heatmap based on the transcripts of the 1430 genes in the green oval of B. Genes above the dotted line are upregulated between Ctrl and EBP; genes below are downregulated between Ctrl and EBP

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