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Fig. 7 | BMC Biology

Fig. 7

From: Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Fig. 7

Tissue selective effect of AF1 mutations. Mutation-induced changes in the expression of progesterone-regulated genes on GD3 and GD4.5 are tissue-dependent. The epithelial, glandular, or stromal expression of the indicated genes is based on literature studies and may be developmental stage-specific. The log2 fold change is based on DESeq analysis of RNA-Seq data, n = 3 for GD3 and n = 4 for GD4.5 samples. Bars with an asterisk sign indicate significant change (padj < 0.05). Positive log2 fold changes indicate upregulation whereas negative log2 fold changes indicate downregulation in the mutant. Note that the large log2 fold value for Cyp26a1 is due to one large outlier, and the change is not significant (padj = 0.11)

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BMC Biology

ISSN: 1741-7007

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