Fig. 3
From: Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure
Specific deletion of tPA in PV interneurons affects PNNs morphology. A Representative images of PV cells (magenta) and PNNs (yellow) in the somatosensory cortex of adult tPAFlox+/+; PV-Cre+/− mice (cKO) and their control littermates (Ctrl), tPAFlox−/−; PV-Cre+/− mice (Scale bar: 100 μm). Quantitative analysis of the density of PV cells (B) and PNN-containing PV cells (C) in both genotypes. D Average WFA intensity was quantified in both groups. E PNNs were assigned to different categories based on the intensity of WFA staining (Scale bar: 10 μm). The percentage of each PNN subtype (F) and the graph show mean ± sem (N=5 animals; n=4 coronal sections per animal). Mann–Whitney test; *: p<0.05