Fig. 8.
Hif-1α was a fine-tune factor for the effects of hypoxia on mESC differentiation. A The heatmap of logFC values of 1157 merged DEGs in the HvsN_WT, HvsN_shHif-1α, and Hif-1α-OE_vs_Con groups. All DEGs were classified into 5 clusters. B The distributions of LogFC values in the three groups. C The GO terms of the genes in each cluster in A. D The violin plots of logFC values in each cluster. E The level changes of representative genes in each cluster. HvsN_WT, wildtype AB2.2 cells on differentiation day 4 under hypoxia versus normoxia; HvsN_shHif-1α, shHif-1α AB2.2 cells on differentiation day 4 under hypoxia versus normoxia; Hif-1α-OE_vs_Con, Hif-1α-iOE AB2.2 cells treated with 10 ng/mL Dox versus non-Dox control on differentiation day 4; *, significant (P<0.05)