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Fig. 9. | BMC Biology

Fig. 9.

From: Hypoxia is fine-tuned by Hif-1α and regulates mesendoderm differentiation through the Wnt/β-Catenin pathway

Fig. 9.

A working model of hypoxia and Hif-1α on mESC differentiation. Hypoxia suppressed the mesendoderm differentiation and promoted the ectoderm differentiation of mESCs by inhibiting the Wnt/β-Catenin pathway. The inhibition of the Wnt/β-Catenin pathway was through the PI3K/Akt/GSK3β axis. Hif-1α, on the contrary, promoted the mesendoderm differentiation and suppressed the ectoderm differentiation, which was at least partially through the Wnt/β-Catenin pathway as well

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BMC Biology

ISSN: 1741-7007

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