Fig. 4

Gait changes in footfall pattern in spontaneous walk after stroke. A Schematic set-up of runway walks from bottom perspective. B Movement speed of individual fore- and hindlimbs during spontaneous walk. C Footfall profile of single mouse without injury. D Footfall profiles of a normalized locomotor cycle showing the stance and phase start and end of three individual control mice (left) and stroked mice (right). E Ratio of asynchronization at baseline, 3, 7, 14, 21 dpi. F Duration of a cycle. G, H Comparison of cycle duration between stance and swing time in a time course. I Schematic view on analysis of positioning paws to body centers. J Profile of paw angles relative to body center of an individual animal. K Comparison of angles of individual paws to body center in a time course. Data are shown as mean distributions where the white dot represents the mean. Boxplots indicate the 25 to 75% quartiles of the data. Each dot in the plots represents one animal and significance of mean differences between the groups was assessed using repeated ANOVA with post hoc analysis. Asterisks indicate significance: ^*P < 0.05, ^**P < 0.01, ^***P < 0.001