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Fig. 3 | BMC Biology

Fig. 3

From: HP1a-mediated heterochromatin formation promotes antimicrobial responses against Pseudomonas aeruginosa infection

Fig. 3

The imd-mediated antimicrobial response in the Drosophila fat body is necessary for heterochromatin-mediated resistance to P. aeruginosa infection. A The fat body promotes antimicrobial responses through the imd pathway upon infection by Gram-negative bacteria. B, C Relative mRNA expression in the fat body before PA14 infection. n = 8 flies/group. Data are shown as mean ± SD and ***p < 0.001 by Student’s t-test. D The survival curve and median survival in flies with fat body-specific C564-driven +, HP1a, imd RNAi, and HP1a; imd RNAi after PA14 infection. n = 40 flies/group. **p < 0.01, ***p < 0.001 by log-rank test. ns, not significant

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BMC Biology

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