Fig. 4

Correlation between chromatin accessibility and gene expression. A Histogram of Pearson’s correlation of all (blue) and significantly correlated (orange) promoter accessibility and gene expression pairs. The number of pairs are indicated with inset numbers. B Clusters of promoter accessibility and gene expression for significant (P<0.05) (i) positive and (ii) negative correlation relative to random. C Histograms of correlation for all (blue) and significantly correlated peak and gene pairs (orange) and associated statistics. The upper histogram includes all mapped peak-gene pairs, while the lower includes only the maximally correlated peak for each gene (below). D Clustered peak accessibility and corresponding expression profiles for significantly positively (i) or negatively (ii) correlated gene-peak mappings