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Fig. 6 | BMC Biology

Fig. 6

From: Comparative epigenomics reveals the impact of ruminant-specific regulatory elements on complex traits

Fig. 6

GWAS signal enrichment analysis of regulatory elements (REs) for complex traits and diseases. GWAS signals enrichment analysis of the characterized REs for 44 and 52 complex traits in cattle (A) and humans (B), respectively. “Blue” represents traits that were only significantly enriched in cattle-specific REs (CS-REs) in A. “*” indicates P < 1.0e−5. ACE, ACP, RSE, RSP, CSE, CSP, HMPSP, HMPSE, HSE, and HSP stand for all-conserved enhancers, all-conserved promoters, ruminant-specific enhancers, ruminant-specific promoters, cattle-specific enhancers, cattle-specific promoters, human-pig-mouse-specific enhancers, human-pig-mouse-specific promoters, human-pig-specific enhancers, human-pig-specific promoters, human-specific enhancers, human-specific promoters, respectively. C, D Pearson’s correlations of enrichment degrees (−log10P) across 52 human traits calculated by using the stratified linkage disequilibrium score regression (LDSC) and the count-based marker-set test

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