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Fig. 6 | BMC Biology

Fig. 6

From: De novo emergence, existence, and demise of a protein-coding gene in murids

Fig. 6

Phases of gene life-cycle during evolution. The upper scheme represents a locus, which does not produce any transcript. Such a locus can give rise to a lncRNA - emergence of a pol II promoter will be sufficient to produce a non-coding transcript. A promoter can emerge from a random sequence or through a solo LTR insertion. The initial transcript at the locus will likely be a lncRNA with variable exon–intron structure as mRNA processing mechanisms will recognize with variable efficiency cryptic splice donors and acceptors as well as poly(A) sites. Such a lncRNA can evolve into a protein-coding gene through recycling a protein-coding sequence from a processed pseudogene inserted into the locus

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