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Fig. 3 | BMC Biology

Fig. 3

From: The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors

Fig. 3

GO enrichment and correlational clustering analysis. A Top 15 enriched GO terms associated with the DEGs in tolerant and sensitive strains. The Y-axis indicates gene functions, and the X-axis indicates the percentage of total DEGs in a given GO category (gene ratio). B String interaction network of candidate genes taken from highly correlated modules (modules 2 to 5, Additional file 8: Fig. S4) of the MCC analysis for the treated samples of the tolerant strains (PPI enrichment p-value < 1×10−16). Up-regulated genes are shown in red, and down-regulated in blue. The genes with yellow labels are part of the serine peptidase cluster, while those with borders in bold were selected for further validation using RNAi knockdown or gene disruption lines

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