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Fig. 2 | BMC Biology

Fig. 2

From: An IGF1-expressing endometrial stromal cell population is associated with human decidualization

Fig. 2

IGF1+ stromal cells initiate endometrial decidualization. A The cell cluster of stromal cells (22480 cells) was re-clustered into seven sub-clusters visualized by UMAP. B Violin plots of representative markers for seven main sub-clusters of stromal cells. C Immunofluorescence staining of MMP11, ADAMTS5, FABP5, PLA2G2A, PRL, and IGFBP1 in the endometrium (Endometrium, n = 3) and decidua (Decidua, n = 3). Scale bar, 20 μm. D Bubble diagram showing the average expression of selected genes for Rem_SC and dRem_SC. E Primary decidual stromal cells (DSCs) were treated with the rh-IGF1 (2 ng/mL), rh-PRL (0.1 ng/mL), or vehicle for 48 h. And then the mRNA expression levels of these genes in DSCs were measured by qRT-PCR (n = 6). Data were presented as mean ± SEM and analyzed by t test. (ns, no significance; *, p < 0.05; **, p < 0.01; ***, p < 0.001). F Diagram showed that IGF1+ stromal cells initiate endometrial decidualization under regulation of progesterone and estrogen

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