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Fig. 3 | BMC Biology

Fig. 3

From: Berberine increases stromal production of Wnt molecules and activates Lgr5+ stem cells to promote epithelial restitution in experimental colitis

Fig. 3

Gene expression profiling of rectal samples of BBR-treated colitis mice. A, B GO and KEGG pathway analyses showing up-regulated gene clusters by BBR in colitis mice. C, D GO and KEGG pathway analyses showing down-regulated gene clusters by BBR in colitis mice. E, F Heatmaps of inflammation-related and Jak-Stat signaling pathway genes, n=3 per group. G qPCR analysis of circadian rhythm genes in rectal samples of normal mice, colitis mice, normal mice receiving BBR, and colitis mice receiving BBR, which were collected at different time points of the day, n=3 per group. Data are presented as means ± SEM in G. Two-way ANOVA with Fisher’s LSD post hoc analysis (α = 0.05) was applied in G. * p<0.05, ** p<0.01, *** p<0.001. p<0.05 was considered as statistically significant

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