Table 1 Functional enrichment of ER genes upregulated in SD and Mito genes upregulated and downregulated in SD (top 10 biological processes with strength of enrichment > 1)
From: Increased interaction between endoplasmic reticulum and mitochondria following sleep deprivation
#Term ID | Term description (biological process) | Strength | False discovery rate | Observed gene count | Background gene count |
|---|---|---|---|---|---|
ER genes upregulated in SD | |||||
 GO:0042026 | Protein refolding | 1.77 | 0.00056 | 4 | 15 |
 GO:0006611 | Protein export from nucleus | 1.19 | 0.0013 | 6 | 87 |
 GO:0006986 | Response to unfolded protein | 1.11 | 0.0027 | 6 | 104 |
 GO:0051085 | Chaperone cofactor-dependent protein refolding | 1.49 | 0.0034 | 4 | 29 |
 GO:0031532 | Actin cytoskeleton reorganization | 1.21 | 0.0049 | 5 | 69 |
 GO:0034620 | Cellular response to unfolded protein | 1.18 | 0.0061 | 5 | 74 |
 GO:0071320 | Cellular response to camp | 1.27 | 0.0132 | 4 | 48 |
 GO:1900024 | Regulation of substrate adhesion-dependent cell spreading | 1.23 | 0.0183 | 4 | 53 |
 GO:0098974 | Postsynaptic actin cytoskeleton organization | 1.48 | 0.0259 | 3 | 22 |
 GO:0070934 | CRD-mediated mRNA stabilization | 1.95 | 0.0463 | 2 | 5 |
Mito genes upregulated in SD | |||||
 GO:0032543 | Mitochondrial translation | 1.75 | 0.0034 | 4 | 54 |
 GO:0043604 | Amide biosynthetic process | 1.09 | 0.0034 | 7 | 434 |
GO:0006412 | Translation | 1.16 | 0.0053 | 6 | 316 |
 GO:0045333 | Cellular respiration | 1.36 | 0.0241 | 4 | 133 |
 GO:0032981 | Mitochondrial respiratory chain complex i assembly | 1.7 | 0.0273 | 3 | 46 |
 GO:0046034 | ATP metabolic process | 1.25 | 0.0473 | 4 | 172 |
ER genes downregulated in SD | |||||
 GO:1902775 | Mitochondrial large ribosomal subunit assembly | 2.91 | 0.0031 | 2 | 3 |
 GO:0043604 | Amide biosynthetic process | 1.07 | 0.0317 | 4 | 414 |
 GO:0007005 | Mitochondrion organization | 1.1 | 0.0317 | 4 | 388 |
 GO:0006418 | tRNA aminoacylation for protein translation | 1.76 | 0.0348 | 2 | 43 |