Fig. 2
From: Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy
Changes in the overall lipid composition and distribution in TA muscle in response to cold exposure. A Volcano plot of lipid species altered in COLD vs. RT muscle (n = 8). The x-axis indicates the Log2 fold changes (log2FC) of all identified lipid species and the y-axis indicates the negative Log10 P value. B The intensity of TG, LPC, LPE, and SM in the TA muscle of the RT and COLD group mice (n = 8). C Log2 fold changes in significantly changed lipid species in the cold-treated versus RT mice and the corresponding significance values displayed as −log10 (P value) (n = 8). D Volcano plots of TG, LPC, LPE, and SM species altered in COLD vs. RT muscle (n = 8). E The intensity of total fatty acid in the TA muscle of the RT and COLD group mice (n = 8). F The intensity of SFA, MUFA, and PUFA in the TA muscle of the RT and COLD group mice (n = 8). G The intensity of n3-PUFA, n6-PUFA, and the percentages of n6-PUFA/n3-PUFA in the TA muscle of the RT and COLD group mice (n = 8). Error bars represent s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, two-tailed Student’s t-test