Fig. 7
From: Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy
A working model of short-term cold exposure in regulating lipid metabolism in skeletal muscle. Short-term cold exposure leads to increased intramuscular lipid droplet deposition in skeletal muscles by mobilizing the body’s metabolism. Cold promotes the process of lipolysis and fatty acid synthesis in the body to generate free fatty acids to store energy. Consequently, the cold challenge induces muscle lipid remodeling and significant changes in lipid composition, especially triglycerides. Transcriptome results show markedly changed genes involved in fatty acid metabolism and mitophagy. Notably, cold exposure leads to impaired mitochondrial oxidation and enhanced mitophagy process, which is modulated by activated HIF1a signaling