Fig. 2.From: Synaptic modifications transform neural networks to function without oxygenBrain transformation after overwintering avoids hypoxia disturbance on respiratory-related synaptic input (RRSI). Motoneurons receiving native input from the respiratory network (A) were recorded on control (n=10, top) and overwintered frogs (n=12, bottom) exposed to hypoxia. B The representative recording of a control neuron RRSI in baseline conditions (BL) is followed by the hypoxia effect on RRSI (Hx- 5 min) and the absence of RRSI concurrent to network failure (Hx after network failure). Controls’ RRSI in baseline conditions was compared to the last measurements before network failure (C–E). Upon hypoxia, controls presented a decrease in peak area (C) and width 50 (D) preceding network failure, while amplitude was not changed (E). F Representative recordings of an overwintered neuron RRSI in baseline conditions (BL) followed by the same period the hypoxia effect was recorded in controls (Hx- 5min) and after 40 min of hypoxia exposure (Hx- 40 min). In overwintered frogs, hypoxia exposure did not disturb peak area (G), width (H), and amplitude (I). Results were compared using paired t-test; p <0.05 was considered statistically significant (∗)Back to article page