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Fig. 5. | BMC Biology

Fig. 5.

From: Synaptic modifications transform neural networks to function without oxygen

Fig. 5.

Membrane potential and firing frequency are not affected by hypoxia exposure throughout the brain. Neurons from locus coeruleus (LC) in brain slices (left, C) and from the pallium on a forebrain sheet dissection (right, C) were sampled from controls (LC n=8, pallium n=8, top) and overwintered (LC n=10, pallium n=8, bottom) frogs. Membrane potential and firing frequency in response to a 200-pA current step in LC cells and a 60-pA step in pallium cells during baseline conditions were compared  to 40 min of hypoxia exposure. There was no effect of hypoxia (p>0.05, paired t-test) in membrane potential and firing frequency in response to the current step both in LC and pallium neurons from controls (A, B—LC; D, E—pallium) or overwintered (F, G—LC; H, I—pallium) frogs

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