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Fig. 2 | BMC Biology

Fig. 2

From: Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon

Fig. 2

Heatmap of the PMA score calculated at ORI positions identified using known POLE-exo-specific variants (marked on the plot). Samples (rows) and mutation types (columns), both clustered into 3 groups. Columns were clustered using only samples in which the percentage of POLE-exo-specific variants exceeded 20% (bar plot located on the right side). Mutations from clusters A and B were used to calculate the PMA score in the final detection. Bar plots on the right show the percentage of POLE-exo-specific variants (marked in the lower left corner) and the total number of mutations per Mb in each of the samples divided into SigProfiler signatures listed in the upper right corner of the plot. Color-based annotation next to the sample IDs determines the cancer type (COAD, colon adenocarcinoma; LUAD, lung adenocarcinoma; READ, rectum adenocarcinoma; UCEC, uterine corpus endometrial carcinoma; PBCA, pediatric brain cancer)

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