Fig. 5

Correlation of mORI sites with epigenetic features of the genome. A Number of specific features at a given distance from the replication origins, expressed as the fold change with respect to the minimum value from each row. B Number of identified ORI at a specific distance from the chromatin loop anchor. The dashed vertical line shows the loop anchor points, and the red line marks the loop center. Since loops have different sizes but the plot shows a fixed interval of 1MB, the number of ORI was divided by the number of loops which reach this specific length. C Average methylation level of the TCGA samples used for the detection of replication origins at various distances from the top 1000 origin positions. D Number of H2A.Z histone modifications at a specific distance from the replication origins, expressed as the fold change with respect to the minimum value from each row. Individual rows were obtained using various replication origin detection methods and results of the method concordance obtained using the MNVA algorithm