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Fig. 3 | BMC Biology

Fig. 3

From: Neural ensembles in the murine medial prefrontal cortex process distinct information during visual perceptual learning

Fig. 3

Chemogenetic inhibition of mPFC pyramidal neurons is sufficient to affect the process of VPL in two tasks. A A schematic of hM4Di or mCherry virus injection in the mPFC. B Left: a representative image of infected mPFC pyramidal neurons; scale bar: 500 Î¼m. Right: enlarged view of CaMKIIa-hM4Di-mCherry-labeled pyramidal neurons in the prelimbic area indicated by the yellow box in the left figure; scale bar: 100 Î¼m. C Top: schematic of the experimental procedure in the automatic chamber. Bottom: schematic of the experimental procedure in the water maze. D In the training chamber, the pretraining VA and VA after training with CNO and the retesting after training with saline were obtained from the hM4Di and mCherry groups, respectively. hM4Di: n = 6; mCherry: n = 7. E In the water maze, the pretraining VA and VA after training with CNO and the retesting after training with saline were obtained from the hM4Di and mCherry groups, respectively. hM4Di: n = 6; mCherry: n = 7. Data are represented as the mean ± SEM. ∗ , p < 0.05; ∗  ∗ , p < 0.01; ∗  ∗  ∗ , p < 0.005; n.s., not significant (p > 0.05)

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BMC Biology

ISSN: 1741-7007

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