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Fig. 2 | BMC Biology

Fig. 2

From: Targeting the gut-lung axis by synbiotic feeding to infants in a randomized controlled trial

Fig. 2

Discriminant taxa between the prebiotic and synbiotic groups at 6 months of age. a A cladogram presenting a significantly higher relative abundance of Bifidobacteriaceae in the synbiotic group (orange) and a higher relative abundance of Erysipelotrichaceae, Lachnospiraceae, and Eubacteriaceae in the prebiotic group (blue) at age 6 months, i.e., 5 months after the start of the intervention. LEfSe was used to investigate the discriminant taxa, and the LEfSe algorithm uses the Kruskal–Wallis sum rank test, unpaired Wilcoxon rank-sum test, and LDA, where α = 0.05 and LDA threshold = 2.0. b A heatmap presenting that multivariable analysis using MaAsLin2 identified that Bifidobacteriaceae correlated with the intervention (synbiotic feeding) (p = 0.02) and that Erysipelotrichaceae were strongly associated with antibiotic treatment (p < 0.001) (Benjamini-Hochberg, q-values were q = 0.2 for Bifidobacteriaceae and q = 0.0009 for Erysipelotrichaceae)

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