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Fig. 4 | BMC Biology

Fig. 4

From: Epigenome-wide analysis of aging effects on liver regeneration

Fig. 4

Mapping of regenerative DMRs to differentially expressed genes (DEGs) during liver regeneration. A Heat maps of DEGs at different time points of liver regeneration after PHx. Numbers of up- (top, up) and down-regulated genes (bottom, dn) are indicated on the left. Hour (h), day (d), week (w). B Numbers of up-regulated DEGs (up-DEGs) mapped by regenerative hypo-DMRs and down-regulated DEGs (down-DEGs) mapped by regenerative hyper-DMRs in the R1:R0, R2:R0, and R4:R0 groups. Gene Set Enrichment Analysis (GSEA) showing pathways enriched in up-DEGs and down-DEGs mapped by regenerative hypo-DMRs and hyper-DMRs, respectively, in the R1:R0 (C), R2:R0 (D), and R4:R0 (E) paradigms. Abbreviations: H, hallmark; CP, canonical pathway; GO, gene ontology; FDR, false discovery rate; n1/n2, the number of DEGs enriched in specific pathways (n1) over the total number of query DEGs (excluding putative genes) (n2)

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