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Fig. 5 | BMC Biology

Fig. 5

From: Epigenome-wide analysis of aging effects on liver regeneration

Fig. 5

Synchronous and inverse changes between aging and regenerative DMRs. (A1) Numbers of regenerative hypo-DMRs hypermethylated during aging (top) and hyper-DMRs hypomethylated during aging (bottom). (A2) Lists of genes mapped by age-inverse regenerative hypo-DMRs (upper panel) or hyper-DMRs (lower panel), their aging paradigms, and liver-related publications found by PubMed search. Six showed liver-related functions (L), with or without additional functions in regeneration (R) or aging (A). B1 Numbers of DMRs that are synchronously hypomethylated or hypermethylated during liver aging and regeneration. B2 Lists of Hallmark (H) and Gene Ontology (GO) pathways enriched in genes whose promoter regions were mapped by early (A8:A2) age-synchronous regenerative hypo-DMRs

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