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Fig. 2 | BMC Biology

Fig. 2

From: Hypoxia induces alterations in tRNA modifications involved in translational control

Fig. 2

Expression pattern of RNA modification enzymes in mouse tissues. A The heatmap shows the expression levels of RNA modification enzymes in six mouse tissues (n = 3). B The expression level of tRNA methyltransferase 10 homologue A (Trmt10a) obtained by transcriptome sequencing. C The relative expression level of m1G in tRNA-enriched fragments (n = 3, Additional file 10). D The linear correlation of Trmt10a and m1G in tRNA-enriched fragments. E The expression level of tRNA methyltransferase Nsun2 obtained by transcriptome sequencing. F The relative expression level of m5C in tRNA-enriched fragments. G The linear correlation of Nsun2 and m5C in tRNA-enriched fragments. H–K The linear correlation of m1G and m5C in total RNA, mRNA, tRNA-enriched fragments, and 17–50-nt sncRNAs. Pearson correlation coefficients were computed with GraphPad Prism 8. Statistical analysis in B and D was conducted using one-way ANOVA with uncorrected Fisher’s LSD

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