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Fig. 4 | BMC Biology

Fig. 4

From: Hypoxia induces alterations in tRNA modifications involved in translational control

Fig. 4

Altered signature of RNA modifications in mouse tissue total RNA by hypobaric hypoxia exposure. A Schematic diagram of blood routine analysis. B Levels of RBC (red blood cell), HGB (hemoglobin), MCH (mean corpuscular hemoglobin), WBC (white blood cell in peripheral blood) (n = 5~10, Additional file 12). C The heatmap shows the hypoxia response relevant pathway of different tissues. D The retar graph shows the relative RNA modification levels in total RNA between normal (NC) and hypoxia (Hypo) groups across different tissues (n = 3~5, Additional files 10 and 11). The level of each RNA modification in the NC group was considered as 1. E Distribution of RNA modification types shows a significant difference in tissue total RNA between NC and Hypo groups (n = 3~5, Additional files 10 and 11). F Comparison of RNA modifications in different tissues’ total RNA between NC and Hypo groups (n = 3~5, Additional files 10 and 11). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns. not significant. All results are shown as mean ± SEM. Statistical analysis was conducted using Student’s t-test with unpaired

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