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Fig. 6 | BMC Biology

Fig. 6

From: Bulk and single-cell characterisation of the immune heterogeneity of atherosclerosis identifies novel targets for immunotherapy

Fig. 6

Metabolic heterogeneity of immune cell populations, especially macrophages. a Boxplot showing the metabolic pathway activity of the major immune cell populations. b Dotplot showing the activity of the top 20 variable metabolic pathways in the macrophage subpopulations (left). Boxplot showing the activity of all metabolic pathways in the macrophage subpopulations (right). c Volcano plot showing the differentially metabolic pathways between SPP1+ Mac and TREM2+ Mac. d Boxplot showing the hypoxic score of macrophage subpopulations. Kruskal–Wallis test. e Scatter plots comparing activities of glycolysis, citrate cycle, and oxidative phosphorylation response to hypoxia in SPP1+ Mac. Spearman rank test. f Heatmap showing the correlation between phenotypic score and metabolic activity score in SPP1+ Mac. *, P < 0.05 and Spearman rho > 0.3. Spearman rank test. g Venn diagram showing potential metabolic regulatory targets of SPP1+ Mac

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