Fig. 8

Models of the NorQ^WBD complex with combined data from cryo-EM analysis and AlphaFold predictions. The NorQ hexamer is shown in blue and cyan, the NorD VWA domain in pink with MIDAS residues in red, and the N-terminal domain in gray (d). a Model of the NorQ hexamer bound to the NorD VWA domain based on the AF prediction shown in Fig. 7c and after flexible fitting into the cryo-EM map (Fig. 6b). b Cryo-EM map colored according to the fitted NorQD model shown in a and with the NorQ protomers labeled as in Fig. 6b. c Surface representation of the fitted NorQD model. d The NorD N-terminal domain was added to the fitted NorQD model preserving its relative position as predicted (Fig. 7c)